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research Publications

32. Raeppel, S. et al.
Identification of a novel series of potent RON receptor tyrosine kinase inhibitors
Bioorganic & Medicinal Chemistry Letters 20(2010), March 2010, p. 2745-2749 

31. Pfaller, M. et al.
Activity of MGCD290, a Hos2 inhibitor, in combination with azole antifungals against opportunistic fungal pathogens
Journal of Clinical Microbiology, Dec 2009, p. 3797-3804

30. Gaudette, F. et al.
Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups
Bioorganic & Medicinal Chemistry Letters 20 (2010) 848-852

29. Saavedra, O. et al.
N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases
Bioorganic & Medicinal Chemistry Letters 19 (2009) 6836-6839

28. Therrien, E. et al.
1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM 1)
Bioorganic & Medicinal Chemistry Letters 19 (2009) 6725-6732

27. Mannion, M. et al.
N-(4-(6,7-disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
Bioorganic & Medicinal Chemistry Letters 19 (2009) 6552-6556

26. Tessier, P. et al.
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters 19 (2009) 5684-5688

25. Manku, S. et al.
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters 19 (2009) 1866-1870


24. Raeppel, S. et al.
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
Bioorganic & Medicinal Chemistry Letters 19 (2009) 1323-1328

23. Raeppel, S. et al.
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitors N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103)
Bioorganic & Medicinal Chemistry Letters 19 (2009) 644-649


22. Moradei, O. et al.

Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents

Current Topics in Med Chem, 2008, 8 (June 2008).

 

21. Paquin, I. et al.

Design and synthesis of 4-[s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry Letters, 18(2008), pp. 1067-1071.

 

20. Garcia-Manero, G. et al

Phase I study of the oral isotype-selective histone deacetylase inhibitors MGCD0103 in leukemia .

Blood, 2008 May 21.

 

19. Bonfils, C. et al.

Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human u






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